Jaitak, V and ---, Bandna and Das, Pralay and Kaul , V K and Singh , Bikram and Kumar, Neeraj (2011) One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl Methyl Ketones. Journal of Synthetic Communications, 41. pp. 2727-2737.

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Abstract

Abstract A regioselective base-promoted Michael and Thorpe–Ziegler reaction between aryl methyl ketones and a,b-unsaturated nitrile was carried out in a single step. Different functional groups in addition to active positions were tolerated under this condition. Results indicated that the reaction proceeds in a consecutive manner as double Michael, triple Michael, and Thorpe–Ziegler condensation. By applying click chemistry, double Michael adducts were converted to bis-tetrazoles, which have broad applications in coordination and medicinal chemistry. Supplemental materials are available for this article. Go to the publisher’s online edition of Synthetic Communications1 to view the free supplemental file

Item Type:	Article
Uncontrolled Keywords:	Aryl methyl ketone; tetrazoles; Thorpe–Ziegler condensation; triple Michael reaction
Subjects:	Plant sciences Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	10 Feb 2012 10:35
Last Modified:	02 Jan 2013 12:30
URI:	http://ihbt.csircentral.net/id/eprint/966

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