Kumari, A and Yadav , S K and Pakade, Yogesh B and Singh , Bikram and Yadav, S C (2010) Development of biodegradable nanoparticles for delivery of quercetin. Colloids and Surfaces B: Biointerfaces, 80. pp. 184-192.

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Abstract

The antioxidant molecule quercetin has been encapsulated on poly-d,l-lactide (PLA) nanoparticles by solvent evaporation method for the improvement of its poor aqueous solubility and stability. The surface morphology and average size of PLA and quercetin loaded PLA nanoparticles are 170±25 and 130±30nm respectively. The antioxidant activities of the PLA encapsulated quercetin nanomedicine are identical to free quercetin. The nanoencapsulation efficiency of quercetin evaluated by HPLC and antioxidant assay is 96.7%. The in vitro release kinetics under physiological condition show initial burst release followed by slow and sustained release. The complete release and maximum retention of quercetin is 72 and 96 h respectively. The less fluorescence quenching efficiency of quercetin–PLA nanoparticles than free quercetin on BSA confirms the controlled release of quercetin from PLA nanoparticles. These properties of PLA encapsulated quercetin molecule pave way for encapsulating various therapeutically less useful highly active antioxidant molecules towards the development of better therapeutic compounds.

Item Type:	Article
Uncontrolled Keywords:	Keywords: Quercetin PLA Nanoparticles Encapsulation efficiency Antioxidant In vitro release
Subjects:	Plant sciences
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	13 Jan 2012 06:27
Last Modified:	06 Feb 2012 07:05
URI:	http://ihbt.csircentral.net/id/eprint/919

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