Sharma , A and Sharma, N and Shard, A and Kumar, R and Mohanakrishan, Dinesh and ---, Saima and Sinha, Arun K and Sahal, D (2011) Tandem allylic oxidation–condensation/esterification catalyzed by silica gel: an expeditious approach towards antimalarial diaryldienones and enones from natural methoxylated phenylpropenes. Journal of Organic Biomolecular Chemistry, 9. pp. 5211-5219.

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Abstract

A new one-pot strategy has been developed, wherein abundantly available methoxylated phenylpropenes are directly transformed into corresponding dienones (1,5-diarylpenta-2,4-dien-1-ones) and enones (chalcones and cinnamic esters) via allylic oxidation–condensation or allylic oxidation–esterification sequences. Preliminary antimalarial activity studies of the above synthesized diaryldienones and enones against Plasmodium falciparum (Pf 3D7) have shown them to be promising lead candidates for developing newer and economical antimalarial agents. In particular, two enones (12b and 13b) were found to possess comparatively better activity (IC50 = 4.0 and 3.4 mM, respectively) than licochalcone (IC50 = 4.1 mM), a well known natural antimalarial compound.

Item Type:	Article
Uncontrolled Keywords:	Oxidation-condensation;
Subjects:	Plant sciences Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	09 Feb 2012 05:06
Last Modified:	02 Jan 2013 12:54
URI:	http://ihbt.csircentral.net/id/eprint/955

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