Sandal, I and Bhattacharya, Amita and Saini, U and Kaur, D and Sharma , S and Gulati, Ashu and Kumar, J K and Kumar, Neeraj and Dayma, Joytsna and Das, Pralay and Singh , Bikram and Ahuja, Paramvir Singh (2011) Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound. Chemical Biology, 11. pp. 1-13.

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Abstract Background: Accidental autoclaving of L-glutamine was found to facilitate the Agrobacterium infection of a non host plant like tea in an earlier study. In the present communication, we elucidate the structural changes in Lglutamine due to autoclaving and also confirm the role of heat transformed L-glutamine in Agrobacterium mediated genetic transformation of host/non host plants. Results: When autoclaved at 121°C and 15 psi for 20 or 40 min, L-glutamine was structurally modified into 5-oxo proline and 3-amino glutarimide (a-amino glutarimide), respectively. Of the two autoclaved products, only a-amino glutarimide facilitated Agrobacterium infection of a number of resistant to susceptible plants. However, the compound did not have any vir gene inducing property. Conclusions: We report a one pot autoclave process for the synthesis of 5-oxo proline and a-amino glutarimide from L-glutamine. Xenobiotic detoxifying property of a-amino glutarimide is also proposed.

Item Type: Article
Subjects: Plant sciences
Natural Product Chemistry
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 08 Feb 2012 05:39
Last Modified: 13 Feb 2012 05:54

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