Sharma, N and Sharma , A and Shard, A and Kumar, R and ---, Saima and Sinha, Arun K (2011) Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation– Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene– Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes. Chemistry A European Journal, 17 (10). pp. 350-356.

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Abstract

Abstract: Tandem reactions that involve chemoselective Knoevenagel/Perkin condensation– decarboxylation–Heck/Suzuki coupling or Heck–aldol sequences have been achieved. This enabled the first concise and efficient synthesis of several important hydroxy-functionalized compound classes, such as stilbene–cinnamoyl hybrids (potent protein tyrosine phosphatase1B inhibitors), cinnamoyl–cinnamic acid hybrids, asymmetric distyrylbenzenes, and biarylstyrenes. Previously reported synthesis require multiple steps and protection/deprotection manipulations

Item Type:	Article
Uncontrolled Keywords:	C-C coupling · condensation · olefination · palladium · stilbenoids
Subjects:	Plant sciences Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	08 Feb 2012 05:28
Last Modified:	02 Jan 2013 12:55
URI:	http://ihbt.csircentral.net/id/eprint/941

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