Bafana, A and Dutt, Som and Kumar, Amit and Kumar, Sanjay and Ahuja, Paramvir Singh (2011) The basic and applied aspects of superoxide dismutase. Journal of Molecular Catalysis B:Enzymatic, 68. pp. 129-138.

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Superoxide dismutase (SOD) is among the most potent antioxidants known in nature and is an important constituent of cellular defence against oxidative stress. The enzyme shows several interesting properties like very high catalytic rate of reaction and high stability to physico-chemical stress. It has also attracted widespread interest due to its therapeutic potential. Oxidative stress is known to be involved in pathophysiology of several diseases and SOD supplementation has been shown to be beneficial in treatment or prevention of such diseases. However, it is yet to be developed into effective, reliable and safe antioxidant therapy. Current review focuses on the physiological importance of SOD, and developments and obstacles in its therapeutic applications for treatment of various disorders. The review also summarizes SOD-based products and patents, its potentiation to improve efficacy, and major clinical trials of SOD in human subjects. Besides, latest literature on phylogeny and biochemistry of the enzyme is also reviewed.

Item Type: Article
Uncontrolled Keywords: Orgotein; Erythrocuprein; Clinical trial; Phylogeny; Mutagenesis
Subjects: Nutraceuticals
Plant Biotechnology
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 30 Dec 2011 03:28
Last Modified: 06 Feb 2012 06:06

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