Sinha, Arun K and Joshi, B P and Sharma, A and Goel, H C and Prasad, J (2004) Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: Isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii. Natural Product Research, 18 (3). pp. 219-223. ISSN 1478-6419

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Abstract

Ultrasound-assisted synthesis of bioactive isoacoramone ( 1), a metabolite of Piper marginatum and Acorus tararinowii, has been achieved by oxidation of toxic beta-asarone ( 2) with potassium permanganate/copper sulphate/alumina into asaronaldehyde ( 3) followed by treatment with ethylmagnesium iodide to provide 1-(2,4,5-trimethoxy) phenyl-1-propanol (4) which upon further oxidation with potassium permanganate/ copper sulphate afforded 1 in 64% yield (overall 32%). Toxicological evaluation of 1 reveals it to be nontoxic up to 60 mg/kg b. w.

Item Type: Article
Uncontrolled Keywords: Isoacoramone; Piper marginatum; Acorus tararinowii; Toxic b-asarone; Ultrasound irradiation
Subjects: Natural Product Chemistry
Divisions: UNSPECIFIED
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 29 Dec 2011 09:32
Last Modified: 29 Dec 2011 09:32
URI: http://ihbt.csircentral.net/id/eprint/408

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