Sinha, Arun K and Joshi, B P and Sharma, A and Kumar, J K and Kaul , V K (2003) Microwave-assisted rapid synthesis of methyl 2,4,5-trimethoxyphenylpropionate, a metabolite of Cordia alliodora. Natural Product Research, 17 (6). pp. 419-422. ISSN 1478-6419
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Abstract
Microwave assisted condensation of asaronaldehyde (2) with malonic acid in piperidine-AcOH provides 2,4,5-trimethoxycinnamic acid (3) in 87% yield within 4 min, which upon further reduction with PdCl2-HCOOH-aq. NaOH gives 3-(2,4,5-trimethoxy) phenyl propionic acid (4) in 88% yield within 3 min. Esterification of 4 with MeOH-H+ gives methyl 2,4,5-trimethoxyphenylpropionate (1), a metabolite of Cordia alliodora, in 94% yield within 3 min (overall 69% yield).
Item Type: | Article |
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Uncontrolled Keywords: | Cordia alliodora; asaronaldehyde; methyl 2,4,5-trimethoxyphenylpropionate; 2,4,5-trimethoxycinnamic acid; microwave technique |
Subjects: | Natural Product Chemistry |
Divisions: | UNSPECIFIED |
Depositing User: | Dr. Aparna Maitra Pati |
Date Deposited: | 29 Dec 2011 09:19 |
Last Modified: | 29 Dec 2011 09:19 |
URI: | http://ihbt.csircentral.net/id/eprint/376 |
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