Sondhi, N and Bhardwaj, R and Kaur, S and Kumar, Neeraj and Singh , Bikram (2008) Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay. Plant Growth Regulation , 54 (3). pp. 217-224. ISSN 0167-6903

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Abstract

Brassinosteroids are of universal occurrence in plants. They have been reported to affect plant growth and development through a spectrum of physiological responses. Recently they are reported to confer resistance in plants against a number of biotic and abiotic stresses. In the present study, a brassinosteroid was isolated from Aegle marmelos Correa. (Rutaceae) which was characterized to be 24-epibrassinolide (EBL) using various spectroscopic techniques (TLC and ESI-MS analysis). It was evaluated for the antigenotoxicity against maleic hydrazide (MH) induced genotoxicity in Allium cepa chromosomal aberration assay. It was shown that the percentage of chromosomal aberrations induced by maleic hydrazide (0.01%) declined significantly with 24-epibrassinolide treatment. EBL (10(-7) M) proved to be the most effective concentration with 91.8% inhibition. This is the first report on the isolation of 24-epibrassinolide from Aegle marmelos and its antigenotoxic effects against MH employing Allium cepa chromosomal aberration assay.

Item Type:	Article
Uncontrolled Keywords:	Antigenotoxicity; Brassinosteroid; 24-Epibrassinolide; Maleic Hydrazide; Aegle Marmelos
Subjects:	Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	28 Dec 2011 08:56
Last Modified:	06 Feb 2012 06:53
URI:	http://ihbt.csircentral.net/id/eprint/310

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