Bhardwaj , A and Tewary, D K and Kumar, R and Kumar, Vinod and Sinha , Arun K and Shanker, Adarsh (2010) Larvicidal and Structure-Activity Studies of Natural Phenylpropanoids and Their Semisynthetic Derivatives against the Tobacco Armyworm Spodoptera litura (FAB.) (Lepidoptera: Noctuidae). Chemistry and Biodiversity, 7 (1). pp. 168-177. ISSN 1612-1872

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The larvicidal activity of 18 phenylpropanoids, 1-18, including phenylpropenoate, phenylpropenal, phenylpropene, and their semisynthetic analogues, were evaluated against the tobacco armyworm, Spodoptera litura (FAB.), to identify promising structures with insecticidal activity. Amongst various phenylpropanoids, isosafrole, a phenylpropene, showed the best activity, with an LC(50) value of 0.6 mu g/leaf cm(2), followed by its hydrogenated derivative dihydrosafrole (LC(50)=2.7 mu g/leaf cm(2)). The overall larvicidal activity of various phenylpropene derivatives was observed in the following order: isosafrole (6) > dihydrosafrole (16) > safrole (12) > anethole (4) > methyl eugenol (11) > eugenol (13) >beta-asarone (8)> dihydroasarone (18) > dihydroanethole (15). Dihydrosafrole might be a promising compound, although presenting a lower larvicidal activity than isosafrole, because of its better stability and resistance to oxidative degradation (due to the removal of the extremely reactive olefinic bond) in comparison to isosafrole. Such structure-activity relationship studies promote the identification of lead structures from natural sources for the development of larvicidal products against S. litura and related insect pests.

Item Type: Article
Uncontrolled Keywords: Feeding-Deterrent Activity; Stored-Product Insects; Essential Oils; Insecticidal Activity; Coleoptera; Constituents; Bioactivity; Asarone; Cutworm; Plants
Subjects: Natural Product Chemistry
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 28 Dec 2011 04:34
Last Modified: 13 Feb 2012 05:07

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