Katocha, Deepali and Kumarb, Dharmesh and Sharma, Upendra and Kumar, Neeraj and Padwad, Yogendra S. and Lal, Brij and Singh , Bikram (2013) Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora. Journal of Natural Product Communications, 8 (2). pp. 161-164.

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Abstract

Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.

Item Type:	Article
Uncontrolled Keywords:	Amaryllidaceae alkaloids, Betaine, Cytotoxic activity, Zephyranthes grandiflora.
Subjects:	Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	04 Apr 2013 08:24
Last Modified:	04 Apr 2013 08:24
URI:	http://ihbt.csircentral.net/id/eprint/1337

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