Sharma, Upendra and Kumar, Neeraj and Singh , Bikram and Munshi, Renuka K. and Bhalerao, Supriya (2013) Immunomodulatory active steroidal saponins from Asparagus racemosus. Journal of Medicinal Chemistry Research, 22. pp. 573-579.

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Abstract

Asparagus racemosus is used in the Indian traditional system of medicine for improving the general state of health and stress-related immune disorders. Most of the synthetic chemotherapeutic agents available today are immunosuppressants and exert variety of side effects. To overcome these undesired effects of chemotherapeutic agents, botanical-based immunomodulators are often employed as adjuvant therapy. In the present study, immunomodulatory activity of two steroidal saponins shatavaroside A (1) and shatavaroside B (2), isolated from Asparagus racemosus, have been evaluated using polymorphonuclear leucocyte function test. The activity was further confirmed using more sensitive assays such as nitroblue tetrazolium, nitrous oxide, and chemiluminescence assays. Both steroidal saponins were found active at nano concentration (5 ng/ml) and can act as potent immunostimulants.

Item Type:	Article
Uncontrolled Keywords:	Asparagus racemosus; Shatavaroside A; Shatavaroside B; Immunomodulatory activity
Subjects:	Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	03 Apr 2013 07:54
Last Modified:	03 Apr 2013 07:54
URI:	http://ihbt.csircentral.net/id/eprint/1322

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