Shunmugam , Nagarajan and Majumder, Syamantak and Sharma, Upendra Kumar and Rajendran, Saranya and Kumar, Neeraj and Chatterjee, Suvro and Singh , Bikram (2013) Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. Journal Bioorganic & Medicinal Chemistry Letters, 23. pp. 287-290.

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Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control. Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control in ex vivo angiogenesis.

Item Type: Article
Uncontrolled Keywords: Thalidomide Anti-angiogenesis Phthalimide
Subjects: Natural Product Chemistry
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 03 Apr 2013 07:12
Last Modified: 03 Apr 2013 07:12

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