Verma , Praveen Kumar and Bala , Manju and Kumar, Neeraj and Singh , Bikram (2012) Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist. Journal of Current Topics in Medicinal Chemistry, 12. pp. 1422-1435.

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Abstract

Tumor necrosis fector-alpha (TNF-α) is a multifunctional cytokine produced hy nmnocytes. nwcrophages, neutrophils. T-cdls. masl cdls, epithelial cells. ostenhlasts and dendritic cells. It can regulate numerous cellular and hiological processes such as immune function,cell differentiation. proliferation. apoptosis and energy metaholism. It lS also involved in the pathogenesis of multiple chronic inflammatorY or autoimmune diseases. The biologica1 activities of TNF-α mediated by two receptors TNFR I and TNFR2. Its activity can be inhibited hy neutralizing monoclonal antibodies or soluble TNF receptors. The inhibition of its biological activities using anti TNF-α antibodies represents an approved strategy for the treatment nf various diseases like cancer, autoimmune diseases, inflammations etc. The involvemenl of TNF-α cytokine in the various types of diseases provide thc therapeutic rationale for the development of TNF-α antagonist.A large numher of natural and synthetic compounds are currently being investigated for TNF-α inhibitory activity. Since the synthetic molecules arc always associated with their side effects hence it is beneficial to develop the natural strategies as the alternative sources. There arc many medicinal plants which are traditionally used for the treatment of the diseases associated with TNF-α inhibition. Hence, in this review article we make an approach to provide a platform for the development of TNF-α antagonist from natural resources.

Item Type:	Article
Uncontrolled Keywords:	Anti-inflammatory. Natural rroducts. Tnillor necrosis factor-alpha.
Subjects:	Plant sciences Natural Product Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Aparna Maitra Pati
Date Deposited:	07 Mar 2013 11:57
Last Modified:	07 Mar 2013 11:57
URI:	http://ihbt.csircentral.net/id/eprint/1309

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