Daramwar, Pankaj .P and Rincy, Raju and Niloferjahan, Siddiqui and Ramakrishnan , Krithika and Gulati, Arvind and Yadav , Amit and Sharma, Rakesh and Thulasiram, Hirekodathakallu .V (2012) Transformation of (±)-lavandulol and (±)-tetrahydrolavandulol by a fungal strain Rhizopus oryzae. Journal of the Bioresource Technology, 115. pp. 70-74.

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Biotransformation of an irregular monoterpene alcohol, (±)-lavandulol [(±)-5-methyl-2-(1-methylethenyl)- 4-hexen-1-ol] (I) and its tetrahydro derivative, (±)-tetrahydrolavandulol [(±)-2-isopropyl-5-methylhexan- 1-ol] (II) were studied using a soil isolated fungal strain Rhizopus oryzae. Five metabolites, 2-((3,3-dimethyloxiran-2-yl)methyl)-3-methylbut-3-en-1-ol (Ia), 2-methyl-5-(prop-1-en-2-yl)hex-2- ene-1,6-diol (Ib), 2-methyl-5-(prop-1-en-2-yl)hexane-1,6-diol (Ic), 2-(3-methylbut-2-enyl)-3-methylenebutane- 1,4-diol (Id), 5-methyl-2-(2-methyloxiran-2-yl)hex-4-en-1-ol (Ie) have been isolated from the fermentation medium and characterized with lavandulol as a substrate. When tetrahydrolavandulol used as a substrate, two metabolites 2-isopropyl-5-methylhexane-1,5-diol (IIa) and 2-isopentyl-3-methylbutane- 1,3-diol (IIb) have been isolated from the fermentation medium. Biotransformation studies with R. oryzae clearly indicate that the organism initiates the transformation either by hydroxylation at allylic methyl groups or epoxidation of double bond. GC and GCMS analyses indicated that both (R)- and (S)-enantiomers of I and II have been transformed into corresponding hydroxylated or epoxy derivatives, when racemic I and II were used as substrates.

Item Type: Article
Uncontrolled Keywords: Biotransformation Lavandulol Fungus Rhizopus oryzae Tetrahydrolavandulol
Subjects: Plant sciences
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 07 Mar 2013 06:05
Last Modified: 07 Mar 2013 06:44
URI: http://ihbt.csircentral.net/id/eprint/1307

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