Kumar, Vishal and Sharma, Sushila and Sharma, U and Singh , Bikram and Kumar, Neeraj (2012) Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS. Green Chmistry, 14. pp. 3410-3414.

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AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen, methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can be recycled at least three times without any significant effect on activity and selectivity.

Item Type: Article
Uncontrolled Keywords: Synthesis substituted amines isoindolinones catalytic reductive aminationabundantly AlCl3/PMHS
Subjects: Natural Product Chemistry
Depositing User: Dr. Aparna Maitra Pati
Date Deposited: 03 Jan 2013 10:36
Last Modified: 03 Jan 2013 10:36
URI: http://ihbt.csircentral.net/id/eprint/1234

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